Papers
asterisk "*" means the corresponding author.
- Propagation of neuronal micronuclei regulates microglial characteristics. Sarasa Yano, Natsu Asami, Yusuke Kishi, Ikuko Takeda, Hikari Kubotani, Yuki Hattori, Ayako Kitazawa, Kanehiro Hayashi, Ken-Ichiro Kubo, Mai Saeki, Chihiro Maeda, Chihiro Hiraki, Rin-Ichiro Teruya, Takumi Taketomi, Kaito Akiyama, Tomomi Okajima-Takahashi, Ban Sato, Hiroaki Wake, Yukiko Gotoh, Kazunori Nakajima, Takeshi Ichinohe, Takeshi Nagata, Tomoki Chiba, and Fuminori Tsuruta. Nat. Neurosci., 28(3), 487-497 (2025).
doi: 10.1038/s41593-024-01863-5 - Integrative Transcriptomics Reveals Layer 1 Astrocytes Altered in Schizophrenia. Julio Leon, Satoshi Yoshinaga, Mizuki Hino, Atsuko Nagaoka, Yoshinari Ando, Jonathan Moody, Miki Kojima, Ayako Kitazawa, Kanehiro Hayashi, Kazunori Nakajima, Carlo Condello, Piero Carninci, Yasuto Kunii, Chung Chau Hon, Jay W. Shin* and Ken-ichiro Kubo*. bioRxiv., 2024.06.27.601103. (2024). (J. Leon and S. Yoshinaga are co-first authors)
doi: https://doi.org/10.1101/2024.06.27.601103 - A single-cell atlas of transcribed cis-regulatory elements in the human genome. Jonathan Moody, Tsukasa Kouno, Miki Kojima, Ikuko Koya, Julio Leon, Akari Suzuki, Akira Hasegawa, Taishin Akiyama, Nobuko Akiyama, Masayuki Amagai, Jen-Chien Chang, Ayano Fukushima-Nomura, Mika Handa, Kazunori Hino, Mizuki Hino, Tomoko Hirata, Yuuki Imai, Kazunori Inoue, Hiroshi Kawasaki, Toshihiro Kimura, Tomofumi Kinoshita, Ken-ichiro Kubo, Yasuto Kunii, Fernando López-Redondo, Riichiro Manabe, Tomohiro Miyai, Satoru Morimoto, Atsuko Nagaoka, Jun Nakajima, Shohei Noma, Yasushi Okazaki, Kokoro Ozaki, Noritaka Saeki, Hiroshi Sakai, Kuniaki Seyama, Youtaro Shibayama, Tomohisa Sujino, Michihira Tagami, Hayato Takahashi, Masaki Takao, Masaru Takeshita, Tsuyoshi Takiuchi, Chikashi Terao, Chi Wai Yip, Satoshi Yoshinaga, Hideyuki Okano, Kazuhiko Yahamoto, Takeya Kasukawa, Yoshinari Ando, Piero Carninci, Jay W. Shin and Chung-Chau Hon., bioRxiv., 2023.11.13.566791. (2023).
doi: https://doi.org/10.1101/2023.11.13.566791 - Maternal immune activation by polyinosinic-polycytidylic acid exposure causes cerebral cortical dysgenesis through dysregulated cell cycle kinetics of neural stem/progenitor cells. Marie Sasaki, Takayuki Mitsuhashi, Fumiko Goto, Shinsuke Shibata, Ken-ichiro Kubo, Shinju Oku, Akihiro Owashi, and Takao Takahashi. Dev. Neurosci., 45(3), 115-125 (2023).
doi: 10.1159/000529317 - A unique “reversed” migration of neurons in the developing claustrum. Kota Oshima, Satoshi Yoshinaga, Ayako Kitazawa, Yuki Hirota, Kazunori Nakajima*, and Ken-ichiro Kubo*. J. Neurosci., 43(5), 693-708 (2023).
doi: 10.1523/JNEUROSCI.0704-22.2022 - Dab1-deficient deep layer neurons prevent Dab1-deficient superficial layer neurons from entering the cortical plate. Satoshi Yoshinaga, Takao Honda, Ken-ichiro Kubo*, and Kazunori Nakajima*. Neurosci. Res., 180, 23-35 (2022).
doi: 10.1016/j.neures.2022.03.011 - Rhythmic activation of excitatory neurons in the mouse frontal cortex improves the prefrontal cortex-mediated cognitive function. Debabrata Hazra, Satoshi Yoshinaga, Keitaro Yoshida, Norio Takata, Kenji F. Tanaka, Ken-ichiro Kubo*, and Kazunori Nakajima*. Cerebral Cortex, 32 (23), 5243-5258 (2022).
doi: 10.1093/cercor/bhac011 - Comprehensive characterization of migration profiles of murine cerebral cortical neurons during development using FlashTag labeling. Satoshi Yoshinaga, Minkyung Shin, Ayako Kitazawa, Kazuhiro Ishii, Masato Tanuma, Atsushi Kasai, Hitoshi Hashimoto, Ken-ichiro Kubo*, and Kazunori Nakajima*. iScience, 24 (4), Article 102277 (2021).
doi: 10.1016/j.isci.2021.102277 - Human neocortical development as a basis to understand mechanisms underlying neurodevelopmental disabilities in extremely preterm infants. Ken-ichiro Kubo*, Kimiko Deguchi. The Journal of Obstetrics and Gynaecology Resarch, 46(11), 2242-50 (2020).
doi: 10.1111/jog.14468 - Both excitatory and inhibitory neurons transiently form clusters at the outermost region of the developing mammalian cerebral neocortex. Minkyung Shin, Ayako Kitazawa, Satoshi Yoshinaga, Kanehiro Hayashi, Yukio Hirata, Colette Dehay, Ken-ichiro Kubo*, and Kazunori Nakajima*. J. Comp. Neurol., 527(10), 1577-1597 (2019). (M. Shin and A. Kitazawa are co-first authors)
doi: 10.1002/cne.24634 - Drebrin-like (Dbnl) controls neuronal migration via regulating N-cadherin expression in the developing cerebral cortex. Seika Inoue, Kanehiro Hayashi, Kyota Fujita, Kazuhiko Tagawa, Hitoshi Okazawa, Ken-ichiro Kubo, and Kazunori Nakajima. J. Neurosci., 39(4), 678-691 (2019).
doi: 10.1523/JNEUROSCI.1634-18.2018 - ApoER2 controls not only neuronal migration in the intermediate zone, but also termination of migration in the developing cerebral cortex. Yuki Hirota, Ken-ichiro Kubo, Takahiro Fujino, Tokuo T. Yamamoto, and Kazunori Nakajima. Cereb. Cortex, 28 (1), 223-235 (2018).
doi: 10.1093/cercor/bhw369 - Impaired dendritic growth and positioning of cortical pyramidal neurons by activation of aryl hydrocarbon receptor signaling in the developing mouse. Eiki Kimura, Ken-ichiro Kubo, Toshihiro Endo, Wenting Ling, Kazunori Nakajima, Masaki Kakeyama, and Chiharu Tohyama. PLoS One, 12 (8), e0183497 (2017).
doi: 10.1371/journal.pone.0183497 - Association of impaired neuronal migration with cognitive deficits in extremely preterm infants. Ken-ichiro Kubo*, Kimiko Deguchi, Taku Nagai, Yukiko Ito, Keitaro Yoshida, Toshihiro Endo, Seico Benner, Wei Shan, Ayako Kitazawa, Michihiko Aramaki, Kazuhiro Ishii, Minkyung Shin, Yuki Matsunaga, Kanehiro Hayashi, Masaki Kakeyama, Chiharu Tohyama, Kenji F. Tanaka, Kohichi Tanaka, Sachio Takashima, Masahiro Nakayama, Masayuki Itoh, Yukio Hirata, Barbara Antalffy, Dawna D. Armstrong, Kiyofumi Yamada, Ken Inoue*, and Kazunori Nakajima*. JCI Insight, 2 (10), e88609 (2017). (K. Kubo and K. Deguchi are co-first authors)
doi: 10.1172/jci.insight.88609 - Reelin transiently promotes N-cadherin-dependent neuronal adhesion during mouse cortical development. Yuki Matsunaga, Mariko Noda, Hideki Murakawa, Kanehiro Hayashi, Arata Nagasaka, Seika Inoue, Takaki Miyata, Takashi Miura, Ken-ichiro Kubo, and Kazunori Nakajima. Proc. Natl. Acad. Sci. U.S.A., 114 (8), 2048-2053 (2017).
doi: 10.1073/pnas.1615215114
Papers (Domestic)
- 大脳皮質発生を分子・細胞・メタ細胞群の時空間ダイナミクスとして理解する、吉永怜史、神経化学、62(2)、56-62 (2023) （日本神経化学会奨励賞受賞者研究紹介）
- 空間トランスクリプトームと精神疾患研究、吉永怜史, 久保健一郎、 臨床精神医学、52 (2)、193-197 (2023)
- 空間的遺伝子発現解析を用いた精神・神経疾患研究の展望、久保健一郎、日本生物学的精神医学会誌、32(4)、96-199 (2021)
doi: 10.11249/jsbpjjpp.32.4_196 - 環境要因が神経発達症を生じる機構に関する最近の知見、久保健一郎、認知神経科学、22、4-9 (2020)
doi: 10.11253/ninchishinkeikagaku.22.4 - 神経発達障害における白質神経細胞の増加とそのモデルマウス作成の試み、久保健一郎、日本生物学的精神医学会誌、30、108-113 (2019)
doi: 10.11249/jsbpjjpp.30.3_108 - 超早産児における神経発達症の臨床像とその病態、竹内章人，高橋立子，永田雅子，福井美保，荒井洋，城所博之，出口貴美子，久保健一郎，井上健，森岡一朗、日本小児科学会雑誌、123(4)、661-673 (2019)
- 神経発達障害の環境要因と脳の組織構造の変化、久保健一郎、日本生物学的精神医学会誌、29(3)、98-102 (2018)
doi: 10.11249/jsbpjjpp.29.3_98 - 神経発達の生物学的理解を進める必要性について、久保健一郎、日本生物学的精神医学会誌、28(3)、135-139 (2017)
doi: 10.11249/jsbpjjpp.28.3_135